Abemaciclib

Beschreibung

Abemaciclib · CAS 1231929-97-7 · C27H32F2N8. UNII 60UAB198HK.

Identifikation

Berechnete Deskriptoren

Regulatorischer Status

GHS-Gefahreneinstufung

Dokumentierte Verwendungen

• * Indicated in combination with fulvestrant for the treatment of women with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced or metastatic breast cancer with disease progression following endocrine therapy. * Inidicated as monotherapy for the treatment of adult patients with HR-positive, HER2-negative advanced or metastatic breast cancer with disease progression following endocrine therapy and prior chemotherapy in the metastatic setting.
• Abemaciclib is a unique cyclin-dependent kinase inhibitor that is used in combination with an antiestrogen in the treatment of postmenopausal women with metastatic breast cancer. Abemaciclib is associated with a moderate rate of serum aminotransferase elevations during therapy and has been linked to rare cases of clinically apparent liver injury.
• Breast Feeding; Lactation; Antineoplastic Agents; Enzyme Inhibitors; Protein Kinase Inhibitors; Signal Transduction Inhibitors;
• Abemaciclib is approved to be used alone or with other drugs to treat:
• • Breast cancer that is hormone receptor positive (HR+) and HER2 negative (HER2-).
• • In adults with early-stage breast cancer that has spread to the lymph nodes and has a high risk of coming back, it is used with tamoxifen citrate or an aromatase inhibitor as adjuvant therapy.

Synonyme

Abemaciclib; 1231929-97-7; LY2835219; Verzenio; LY-2835219; Verzenios; 60UAB198HK; LY 2835219; LY2835210; LY-2835210; abemaciclibum; RefChem:58097; L01XE50; LY2385219; 806-670-8; LY2835219 free base

Häufige Fragen

Wie lauten CAS-Nummer und Summenformel von Abemaciclib?

CAS 1231929-97-7; Summenformel C27H32F2N8; Molmasse — g/mol.

Unter welchen weiteren Namen ist Abemaciclib bekannt?

Abemaciclib, 1231929-97-7, LY2835219, Verzenio, LY-2835219, Verzenios.

Ist Abemaciclib als gefährlich eingestuft?

20% der GHS-Meldungen enthalten keine Einstufung als Gefahr (1 von 5).

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