Melatonin

Description

Melatonin · CAS 8041-44-9 · C13H16N2O2. UNII JL5DK93RCL. Melting Point: 117; Melting Point: 116-118 °C; Melting Point: 117 °C.

Identification

Computed Descriptors

Physical & Chemical Properties

Physical description & handling notes

• Solid
• Pale yellow leaflets from benzene
• White-cream to yellowish crystalline powder
• In water, 2 g/L at 20 °C; 5 g/L at 50 °C
• >34.8 [ug/mL] (The mean of the results at pH 7.4)
• Melatonin has pKa of 16.51 and -0.69 and is uncharged in the entire pH-range

Regulatory Status

GHS Hazard Classification

Documented Uses

• Melatonin regulates biological rhythms and neuroendocrine functions.
• In the United States, the hormone melatonin is sold, without regulation by the FDA, as a dietary supplement. In most of the rest of the world, it is not sold at all, because it is regulated as a drug and no pharmaceutical company has presented an appropriate regulatory body with a successful new drug application for its use. Some countries allow very low doses-less than 100 mg-to be sold without regulatory approval.
• Derivatives and analogs of melatonin are being used in the development of preventive therapies of Alzheimer's disease.
• Melatonin drugs and supplements have use in treating insomnia, sleep disorders and jet lag; treatment for reducing pain of "cluster headaches; some evidence that melatonin might improve the effectiveness of cancer drugs used to fight tumors in the breast, lung, kidney, liver, pancreas, stomach and colon.
• For more Uses (Complete) data for MELATONIN (7 total), please visit the HSDB record page.
• Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients

Synonyms

Melatonin; 73-31-4; Melatonine; N-Acetyl-5-methoxytryptamine; N-[2-(5-Methoxy-1H-indol-3-yl)ethyl]acetamide; Circadin; 5-Methoxy-N-acetyltryptamine; Melatol; N-(2-(5-Methoxy-1H-indol-3-yl)ethyl)acetamide; Melovine; Melapure; Acetamide, N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-; N-[2-(5-methoxyindol-3-yl)ethyl]acetamide; DTXSID1022421; N-acetyl-5-methoxy-tryptamine; N-(2-(5-Methoxyindol-3-yl)ethyl)acetamide

Frequently Asked Questions

What are the CAS number and molecular formula of Melatonin?

CAS 8041-44-9; molecular formula C13H16N2O2; molecular weight — g/mol.

What other names is Melatonin known by?

Melatonin, 73-31-4, Melatonine, N-Acetyl-5-methoxytryptamine, N-[2-(5-Methoxy-1H-indol-3-yl)ethyl]acetamide, Circadin.

What is the regulatory status of Melatonin?

Documented regulatory listings: Melatonin: Sleep Disorders; CIR / INCI: Antioxidant.

Is Melatonin classified as hazardous?

96.5% of GHS notifications report no hazard classification (139 of 144).

What are the key physical properties of Melatonin?

Melting Point: 117; Melting Point: 116-118 °C; Melting Point: 117 °C; LogP: 1.6.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.

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